RABBIT ANTI USP2

Rabbit anti Human USP2 antibody recognizes USP2 ealso known as ubiquitin carboxyl-terminal hydrolase 2, 41 kDa ubiquitin-specific protease, deubiquitinating enzyme 2, ubiquitin specific protease 12, ubiquitin specific protease 9, ubiquitin thioesterase 2 or ubiquitin-specific-processing protease 2.

The USP2 gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease required for TNF-alpha -induced NF-kB signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified (provided by RefSeq, Aug 2011).

Rabbit anti Human USP2 antibody detects a band of 80 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.