RABBIT ANTI TRANSCRIPTION FACTOR E2F2

Rabbit anti Human transcription factor E2F2 antibody recognizes the transcription factor E2F2.

The protein encoded by the E2F2 gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. E2F2 binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1 (provided by RefSeq, Jul 2008).

Rabbit anti Human E2F2 antibody detects a band of 47 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.