RABBIT ANTI TIMP-1

Rabbit anti Human TIMP-1 antibody recognizes TIMP-1, also known as collagenase inhibitor, erythroid potentiating activity, fibroblast collagenase inhibitor or tissue inhibitor of metalloproteinases 1.

The TIMP1 gene belongs to the TIMP gene family. The protein encoded by the TIMP1 gene is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of TIMP1 is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that TIMP1 inactivation is polymorphic in human females. TIMP1 is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction (provided by RefSeq, Jul 2008).

Rabbit anti Human TIMP1 antibody detects a band of 35 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.