RABBIT ANTI PSMB3
Rabbit anti Human PSMB3 antibody recognizes the PSMB3, also known as proteasome subunit beta type-3, HC10-11 and proteasome theta chain.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMB3 encodes a member of the proteasome B-type family, also known as the T1B family that is a 20S core beta subunit. The 26S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants (provided by RefSeq, Sep 2013).
Rabbit anti Human PSMB3 antibody detects a band of 25 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Disponibilidad | Bajo pedido |
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Marca | BIO-RAD |
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