GOAT ANTI ILF3

Goat anti Human ILF3 antibody recognizes ILF3, also known as M-phase phosphoprotein 4, double-stranded RNA-binding protein 76, dsRNA binding protein NFAR-2/MPP4, interleukin enhancer binding factor 3, 90kD, nuclear factor associated with dsRNA, nuclear factor of activated T-cells 90 kDa or translational control protein 80.

ILF3 gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of ILF3. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of ILF3 that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms (provided by RefSeq, Nov 2008).

Goat anti Human ILF3 antibody detects a band of 106 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.